More uses for genomic junk
نویسندگان
چکیده
منابع مشابه
Transposable Elements: No More 'Junk DNA'
Since the advent of whole-genome sequencing, transposable elements (TEs), just thought to be 'junk' DNA, have been noticed because of their numerous copies in various eukaryotic genomes. Many studies about TEs have been conducted to discover their functions in their host genomes. Based on the results of those studies, it has been generally accepted that they have a function to cause genomic and...
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Alus, the short interspersed repeated sequences (SINEs), are retrotransposons that litter the human genomes and have long been considered junk DNA. However, recent findings that these mobile elements are transcribed, both as distinct RNA polymerase III transcripts and as a part of RNA polymerase II transcripts, suggest biological functions and refute the notion that Alus are biologically unimpo...
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The completion of The ENCODE (Encyclopedia of DNA Elements) Pilot Project marks an important step forward in enriching the human genome sequence with functional information. The Human Genome Project (HGP) produced a sequence that was annotated for potential genes and other genomic features (Lander et al. 2001; Venter et al. 2001; The International Human Genome Sequencing Consortium 2004). This ...
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متن کاملThe Case for Junk DNA
With the advent of deep sequencing technologies and the ability to analyze whole genome sequences and transcriptomes, there has been a growing interest in exploring putative functions of the very large fraction of the genome that is commonly referred to as ‘‘junk DNA.’’ Whereas this is an issue of considerable importance in genome biology, there is an unfortunate tendency for researchers and sc...
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ژورنال
عنوان ژورنال: Nature
سال: 2017
ISSN: 0028-0836,1476-4687
DOI: 10.1038/543183a